Epithalon 10 mg

Epithalon 10 mg

£20.00

Epithalon 10 mg is listed for UK laboratory research. Epitalon is another spelling of the same tetrapeptide, and AEDG denotes its sequence, Ala-Glu-Asp-Gly.

For a mass-based experiment, request the Epithalon specification and ask whether the stated 10 mg refers to peptide content or the supplied salt. Include the product link and a lot number if available.

Research Use Only. Not for human or veterinary use.

Browse the MOTS-c, NAD+, glutathione and Epithalon listings, or return to the research peptides and laboratory materials catalogue.

100 in stock

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Description

Epithalon, Epitalon and AEDG

Epithalon and Epitalon name the synthetic tetrapeptide alanine–glutamic acid–aspartic acid–glycine. Its sequence is abbreviated AEDG. Epithalamin is a pineal extract containing several components. Researchers detected AEDG in one such preparation, but an extract and an isolated peptide are different experimental inputs. [1] [2]

The reference form H-Ala-Glu-Asp-Gly-OH has a molecular weight of 390.35 g/mol. A counterion changes the mass associated with a given amount of peptide. Match the chemical form on the specification before using a reference molecular weight. [1] [11] See the Epithalon identity and research-lineage profile for the naming history.

What to confirm about the 10 mg fill

Ask which lot is being offered and request its available records. Match the sample identifier to the specification before comparing results. The batch-report guide sets out the information to request.

Evidence for the listed Epithalon material
Question Record to check
Which form is supplied? Look for the AEDG sequence, terminal groups, salt or free form, and any other declared ingredients.
What does 10 mg represent? Check whether the figure refers to net peptide content or to the mass of the whole preparation. An identity result by itself cannot answer this.
What does the purity figure measure? Read the method, sample identifier and integration basis. Relative peak area and measured peptide content answer different questions.

The analytical testing guide explains how to read identity, purity and quantitative results.

On receipt

Keep the container label, lot number, specification and any report together. Check the handling and storage conditions for that presentation before use. The storage and stability guide explains which details depend on form and packaging.

Ordering Epithalon 10 mg

Use the price and availability shown in the live product panel when ordering. Knockout Labs supplies UK research buyers aged 18 or over, including organisations and individual research buyers, with orders subject to manual approval under its research-use and buyer-eligibility policy. Current shipping information is on the UK delivery page.

For a product or documentation query, contact Knockout Labs technical support with the product name and, where available, the lot or order reference. This helps identify the relevant record.

Research Use Only. Not for human or veterinary use.

What do the Epithalon studies show?

Fibroblast studies measured telomerase, telomere length and cell division. Circadian studies measured hormones or gene expression. A mouse survival study found a difference among the longest-lived animals while mean lifespan did not increase. These endpoints do not establish a human longevity or sleep benefit. [3] [4] [9] [10] [12]

Read the cell, circadian and survival findings

Cell culture and telomere maintenance

Researchers observed telomerase activity and longer telomeres in treated human fetal fibroblasts. In a follow-up experiment, the treated fibroblasts continued dividing after the untreated cultures stopped. A passage is a transfer to fresh culture conditions. It cannot be translated into years of human life. [3] [4]

Later work reported different telomere-maintenance responses in normal cell cultures and breast cancer cell lines. Read that study together with its published correction. Another experiment found changes in neuronal differentiation markers in human gingival stem cells. Those markers do not demonstrate functioning neurons. [5] [6] [7]

Melatonin and circadian measurements

One study in older rhesus monkeys reported altered hormone patterns. Isolated rat pineal glands showed no significant change in melatonin secretion. A human study measured a urinary melatonin metabolite and clock-gene expression after a particular sublingual preparation. These different experiments do not establish that the material listed here improves sleep. [8] [9] [10] [11]

Mean and maximum lifespan in mice

In female Swiss-derived SHR mice the authors reported higher maximum lifespan without an increase in mean lifespan. The distinction matters when reading a claim about “lifespan”: the oldest animal and the group average answer different questions. [12]

Epithalon product questions

Is Epitalon a different listing?

Epitalon is an alternative spelling of Epithalon. AEDG identifies the four-residue sequence. Use the offered material’s specification to identify its actual form.

Does a 10 mg label give the concentration?

The listed figure is a mass. Concentration also requires the measured or stated amount on a defined basis and the final volume.

References

  1. FDA Substance Registration System. Epitalon, UNII O65P17785G. Reference identity.
  2. Khavinson et al. (2017). AEDG detection in a pineal peptide complex. Bulletin of Experimental Biology and Medicine 164:41–43. doi:10.1007/s10517-017-3922-8.
  3. Khavinson, Bondarev & Butyugov (2003). Epitalon and telomerase activity in human somatic cells. Bulletin of Experimental Biology and Medicine 135:590–592. doi:10.1023/A:1025493705728.
  4. Khavinson et al. (2004). Epitalon and the proliferative capacity of human fibroblasts. Bulletin of Experimental Biology and Medicine 137:503–506. doi:10.1023/B:BEBM.0000038164.49947.8C.
  5. Al-dulaimi et al. (2025). Epitalon, telomere elongation and telomere-maintenance pathways. Biogerontology 26:178. Read with reference 6.
  6. Al-dulaimi et al. Correction to the 2025 telomere study. Published 15 November 2025; Biogerontology 27:1 (2026).
  7. Khavinson et al. (2020). AEDG, neurogenic markers and a possible epigenetic mechanism. Molecules 25:609.
  8. Khavinson, Goncharova & Lapin (2001). Epitalon and neuroendocrine measurements in senescent monkeys. Neuroendocrinology Letters 22:251–254.
  9. Djeridane et al. (2003). Epitalon and melatonin secretion by isolated rat pineal glands. Journal of Endocrinological Investigation 26:211–215. doi:10.1007/BF03345159.
  10. Ivko et al. (2021). AEDG, melatonin synthesis and circadian-gene expression. Advances in Gerontology 11:53–58.
  11. US FDA (2026). Epitalon briefing for the Pharmacy Compounding Advisory Committee, pp. 9, 25–26 and 36. Used for reference chemistry and the agency’s assessment of the human study.
  12. Anisimov et al. (2003). Epitalon, lifespan and spontaneous tumours in female Swiss-derived SHR mice. Biogerontology 4:193–202.

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