Epithalon
Epithalon, also written Epitalon, is the tetrapeptide Ala–Glu–Asp–Gly. Its one-letter sequence is AEDG. When a paper mentions pineal peptides, first check whether the researchers examined this defined molecule or a mixture such as Epithalamin. The distinction changes what the experiment can tell you. [1] [2]
Epithalon, Epitalon and the AEDG sequence
| Field | Reference record |
|---|---|
| Sequence | Ala–Glu–Asp–Gly; AEDG |
| Unmodified terminal notation | H-Ala-Glu-Asp-Gly-OH |
| Reference formula | C14H22N4O9 |
| Reference molar mass | 390.35 g/mol, without an added counter-ion |
| Reference CAS | 307297-39-8 |
The FDA substance register lists Epitalon and Epithalon under UNII O65P17785G. The table gives the reference form without an added counter-ion. In its chemistry briefing, FDA lists a different formula and molar mass for Epitalon acetate. Check which form a supplier specifies before using 390.35 g/mol in a calculation. [1] [6]
Epithalamin is a different material
Epithalamin is a pineal peptide preparation. In a study of a pineal polypeptide complex, the investigators detected AEDG among several peptide species. This establishes that the specified complex contained AEDG. A result obtained with the whole preparation still belongs to that mixture. [2]
What the telomere experiments measured
A 2003 experiment added Epithalon to cultured human fetal fibroblasts. The authors reported telomerase activity and telomere elongation in these cells. The study followed a cell culture and measured neither lifespan in people nor an effect of a commercial vial. [3]
In a later study, Al-dulaimi and colleagues measured telomere length, hTERT gene expression and telomerase enzyme activity separately. In the two breast cancer cell lines, hTERT expression increased while the enzyme activity showed no significant increase under the conditions tested. The journal corrected figures 1–3. Read the corrected figures alongside the methods before comparing the cell lines. [4] [5]
Use the pineal peptide and telomere research guide to follow the preparations and study designs. When recording a finding, include the cell type, the material used and whether the measurement was gene expression, enzyme activity or telomere length.
Connect the entity to the container
The Epithalon 10 mg product page identifies the nominal vial presentation. If a protocol requires AEDG on a free-peptide mass basis, ask whether the stated 10 mg is expressed on that basis and which content result supports it for the offered lot.
Resolve a conflicting synonym through compound names and identifiers. For a particular vial, quote the product and lot through batch documentation and request the specification that defines the sequence, termini, counter-ion and mass basis.
Read the supplied report using the Certificate of Analysis guide, starting with the material and lot identifiers.
Continue the material check
| Resource | Why open it |
|---|---|
| Longevity and Mitochondrial Research Compounds | Browse the ageing, mitochondrial and redox research category. |
| Compound Index | Find another molecular profile without confusing it with a vial. |
| NAD+, MOTS-c and Glutathione Compared | Compare three chemical classes associated with metabolic research. |
Sources and scope
- FDA substance register · Epitalon, UNII O65P17785G Reference formula, synonyms and CAS mapping.
- Identification of peptide AEDG in a pineal polypeptide complex (2017) Chemical identification of AEDG within the preparation studied.
- Epithalon, telomerase activity and telomere length in cultured fibroblasts (2003) The observations concern a human fetal fibroblast culture.
- Al-dulaimi and colleagues · Epitalon and telomere maintenance in human cell lines (2025) The updated article distinguishes expression, enzyme activity and alternative lengthening of telomeres.
- Biogerontology · Correction to the Epitalon cell-line study The November 2025 notice supplies replacement figures 1–3.
- FDA Pharmacy Compounding Advisory Committee · Epitalon chemistry briefing (July 2026) Table 1 identifies the reference free form and acetate separately. The table describes those entities.